Early Cancer Diagnostics

Biomarker concepts for early cancer detection

Publications

2024

Routila, E.; Mahran, R.; Salminen, S.; Irjala, H.; Haapio, E.; Kytö, E.; Ventelä, S.; Petterson, K.; Routila, J.; Gidwani, K.; Leivo, J. Identification of Stemness-Related Glycosylation Changes in Head and Neck Squamous Cell Carcinoma. BMC Cancer 202424 (1), 443.

Welsh, J. A.; Goberdhan, D. C. I.; O’Driscoll, L.; Buzas, E. I.; Blenkiron, C.; Bussolati, B.; Cai, H.; Di Vizio, D.; Driedonks, T. A. P.; Erdbrügger, U.; Falcon‐Perez, J. M.; Fu, Q.; Hill, A. F.; Lenassi, M.; Lim, S. K.; Mahoney, M. G.; Mohanty, S.; Möller, A.; Nieuwland, R.; Ochiya, T.; Sahoo, S.; Torrecilhas, A. C.; Zheng, L.; Zijlstra, A.; Abuelreich, S.; Bagabas, R.; Bergese, P.; Bridges, E. M.; Brucale, M.; Burger, D.; Carney, R. P.; Cocucci, E.; Crescitelli, R.; Hanser, E.; Harris, A. L.; Haughey, N. J.; Hendrix, A.; Ivanov, A. R.; Jovanovic‐Talisman, T.; Kruh‐Garcia, N. A.; Ku’ulei‐Lyn Faustino, V.; Kyburz, D.; Lässer, C.; Lennon, K. M.; Lötvall, J.; Maddox, A. L.; Martens‐Uzunova, E. S.; Mizenko, R. R.; Newman, L. A.; Ridolfi, A.; Rohde, E.; Rojalin, T.; Rowland, A.; Saftics, A.; Sandau, U. S.; Saugstad, J. A.; Shekari, F.; Swift, S.; Ter‐Ovanesyan, D.; Tosar, J. P.; Useckaite, Z.; Valle, F.; Varga, Z.; Van Der Pol, E.; Van Herwijnen, M. J. C.; Wauben, M. H. M.; Wehman, A. M.; Williams, S.; Zendrini, A.; Zimmerman, A. J.; MISEV Consortium; Théry, C.; Witwer, K. W. Minimal Information for Studies of Extracellular Vesicles (MISEV2023): From Basic to Advanced Approaches. J of Extracellular Vesicle 202413 (2)

2023

Islam, Md. K.; Khan, M.; Gidwani, K.; Witwer, K. W.; Lamminmäki, U.; Leivo, J. Lectins as Potential Tools for Cancer Biomarker Discovery from Extracellular Vesicles. Biomark Res 202311 (1), 85

Jain, S.; Parimelazhagan Santhi, P.; Vinod, R.; Afrin Ruma, S.; Huhtinen, K.; Pettersson, K.; Sundfeldt, K.; Leivo, J.; Gidwani, K. Aberrant Glycosylation of Α3 Integrins as Diagnostic Markers in Epithelial Ovarian Cancer. Clinica Chimica Acta 2023543, 117323.

Scott, E.; Hodgson, K.; Calle, B.; Turner, H.; Cheung, K.; Bermudez, A.; Marques, F. J. G.; Pye, H.; Yo, E. C.; Islam, K.; Oo, H. Z.; McClurg, U. L.; Wilson, L.; Thomas, H.; Frame, F. M.; Orozco-Moreno, M.; Bastian, K.; Arredondo, H. M.; Roustan, C.; Gray, M. A.; Kelly, L.; Tolson, A.; Mellor, E.; Hysenaj, G.; Goode, E. A.; Garnham, R.; Duxfield, A.; Heavey, S.; Stopka-Farooqui, U.; Haider, A.; Freeman, A.; Singh, S.; Johnston, E. W.; Punwani, S.; Knight, B.; McCullagh, P.; McGrath, J.; Crundwell, M.; Harries, L.; Bogdan, D.; Westaby, D.; Fowler, G.; Flohr, P.; Yuan, W.; Sharp, A.; de Bono, J.; Maitland, N. J.; Wisnovsky, S.; Bertozzi, C. R.; Heer, R.; Guerrero, R. H.; Daugaard, M.; Leivo, J.; Whitaker, H.; Pitteri, S.; Wang, N.; Elliott, D. J.; Schumann, B.; Munkley, J. Upregulation of GALNT7 in Prostate Cancer Modifies O-Glycosylation and Promotes Tumour Growth. Oncogene 202342 (12), 926–937.

2022

Shruti Jain, Nimrah Nadeem, Benjamin Ulfenborg, Maria Mäkelä, Shamima Afrin Ruma, Joonas Terävä, Kaisa Huhtinen, Janne Leivo, Björn Kristjansdottir, Kim Pettersson, Karin Sundfeldt, & Kamlesh Gidwani (2022). Diagnostic potential of nanoparticle aided assays for MUC16 and MUC1 glycovariants in ovarian cancer. International Journal of Cancer.

Md. Khirul Islam, Bert Dhondt, Parvez Syed, Misba Khan, Kamlesh Gidwani, Jason Webber, An Hendrix, Guido Jenster, Tarja Lamminen, Peter J. Boström, Kim Pettersson, Urpo Lamminmäki, & Janne Leivo (2022). Integrins are enriched on aberrantly fucosylated tumour-derived urinary extracellular vesicles. Journal of Extracellular Biology, 1(10).

2021

Vinod R, Mahran R, Routila E, Leivo J, Pettersson K, & Gidwani K (2021). Nanoparticle-Aided Detection of Colorectal Cancer-Associated Glycoconjugates of Extracellular Vesicles in Human Serum. . International journal of molecular sciences.

Joonas Terävä, Alejandra Verhassel, Orsola Botti, Md. Khirul Islam, Janne Leivo, Saara Wittfooth, Pirkko Härkönen, Kim Pettersson, & Kamlesh Gidwani (2021). Primary breast cancer biomarkers based on glycosylation and extracellular vesicles detected from human serum. Cancer Reports.

Md. Khirul Islam, Parvez Syed, Bert Dhondt, Kamlesh Gidwani, Kim Pettersson, Urpo Lamminmäki, & Janne Leivo (2021). Detection of Bladder Cancer with Aberrantly Fucosylated ITGA3. Analytical Biochemistry, 114283.

Erdbrügger U, Blijdorp CJ, Bijnsdorp IV, Borràs FE, Burger D, Bussolati B, Byrd JB, Clayton A, Dear JW, Leivo, J, ….. Falcón-Pérez JM, Grange C, Hill AF, & Martens-Uzunova ES (2021). Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles.. Journal of extracellular vesicles.

2020

Bayoumy, S., Hyytiä, H., Leivo, J., Talha, S., Huhtinen, K., Poutanen, M., Hynninen, J., Perheentupa, A., Lamminmaki, U., Gidwani, K., & Pettersson, K. (2020). Glycovariant-based lateral flow immunoassay to detect ovarian cancer?associated serum CA125. Communications Biology, 3(1)

2019

Islam MK, Syed P, Lehtinen L, Leivo J, Gidwani K, Wittfooth S, Pettersson K, & Lamminmäki U (2019). A Nanoparticle-Based Approach for the Detection of Extracellular Vesicles.. Scientific reports.